Casseroles are the ultimate comfort food—easy to make, hearty, and full of flavor. Whether you’re feeding a crowd or looking for a quick weeknight dinner, these 20 main-dish casserole recipes have you covered. From classic favorites like ground beef and meatloaf casserole to creative twists like Philly cheesesteak or egg casseroles, there’s something for everyone.

Chicken Spaghetti Casserole

Chicken Spaghetti Casserole. Photo credit: Southern Food and Fun.

Creamy, cheesy, and loaded with tender chicken and pasta, this casserole is pure comfort in every bite. With a touch of flavor from a rich tomato base, it’s a hearty dinner that’s as simple to make as it is to enjoy.
Get the Recipe: Chicken Spaghetti Casserole

Unstuffed Pepper Casserole

Unstuffed Pepper Casserole. Photo credit: Southern Food and Fun.

Skip the hassle of stuffing peppers! This dish brings all the savory flavors of stuffed peppers together in a quick and easy layered casserole format, bursting with ground beef, rice, and vibrant bell peppers.
Get the Recipe: Unstuffed Pepper Casserole

Chicken Noodle Casserole

A casserole dish filled with chicken and broccoli.
Chicken Noodle Casserole. Photo credit: Trina Krug.

A classic for a reason, this casserole blends tender chicken, egg noodles, and a creamy sauce. The warm, homestyle flavors make it a go-to dish for an easy family dinner.
Get the Recipe: Chicken Noodle Casserole

Cuban Casserole

A closeup shot of Cuban Casserole in a baking dish.
Cuban Casserole. Photo credit: Keto Cooking Wins.

Take a taste trip to Cuba with this flavorful casserole featuring layers of juicy pork, ham, tangy pickles, and melty Swiss cheese, all baked to golden perfection.
Get the Recipe: Cuban Casserole

Cornbread Casserole

A white casserole dish with cornbread casserole and a silver serving spoon.
Cornbread Casserole. Photo credit: Ginger Casa.

This sweet and savory dish combines the fluffiness of cornbread with a rich and hearty filling, creating a meal that comforts and delights at the same time.
Get the Recipe: Cornbread Casserole

Crockpot Chicken Enchilada Casserole

Crockpot Chicken Enchilada Casserole. Photo credit: Bowl Me Over.

All the bold flavors of chicken enchiladas with none of the fuss! Layered with tortillas and cheese, this crockpot-friendly dish is perfect for slow-simmered deliciousness.
Get the Recipe: Crockpot Chicken Enchilada Casserole

Meatloaf Casserole

A slice of meatloaf topped with melted cheese and herbs on a white plate, with a fork beside it.
Meatloaf Casserole. Photo credit: Southern Food and Fun.

Packed with all the crowd-pleasing flavors of classic meatloaf, this casserole adds a twist with layers of mashed potatoes and vegetables baked in a savory sauce.
Get the Recipe: Meatloaf Casserole

Low Carb Taco Casserole

Taco casserole with fresh vegetables.
Low Carb Taco Casserole. Photo credit: Low Carb – No Carb.

For taco lovers watching their carbs, this casserole is a game-changer. Loaded with seasoned ground beef, gooey cheese, and fresh veggies, it’s healthy without skimping on flavor.
Get the Recipe: Low Carb Taco Casserole

Jalapeno Popper Chicken Casserole

Chicken enchilada casserole with corn and jalapenos.
Jalapeno Popper Chicken Casserole. Photo credit: Call Me PMc.

Love a little heat? This casserole combines creamy chicken with spicy jalapenos and crispy bacon for a dish that’s spicy, cheesy, and absolutely irresistible.
Get the Recipe: Jalapeno Popper Chicken Casserole

Green Bean Hamburger Casserole

Green bean casserole being served with wooden spoon.
Green Bean Hamburger Casserole. Photo credit: Primal Edge Health.

Earthy green beans pair perfectly with seasoned ground beef in this creamy, cheesy casserole that’s hearty and simple to put together.
Get the Recipe: Green Bean Hamburger Casserole

Easy Tuna Noodle Casserole

A casserole dish filled with pasta and peas.
Easy Tuna Noodle Casserole. Photo credit: Real Balanced.

Tuna and egg noodles come together in creamy harmony in this retro-inspired dish. Finished with a crunchy topping, it’s a nostalgic favorite that still wows today.
Get the Recipe: Easy Tuna Noodle Casserole

Hashbrown Casserole

Hashbrown casserole being served.
Hashbrown Casserole. Photo credit: Splash of Taste.

Cheesy, crispy, and golden, this hashbrown casserole is a potato lover’s dream. It’s the kind of meal that brings the family running to the table.
Get the Recipe: Hashbrown Casserole

Hamburger Hashbrown Casserole

Hashbrown and hamburger casserole in white pan.
Hamburger Hashbrown Casserole. Photo credit: One Hot Oven.

Take hashbrowns to the next level by layering them with seasoned ground beef and gooey cheese. It’s hearty, comforting, and seriously satisfying.
Get the Recipe: Hamburger Hashbrown Casserole

Easy Chicken Enchilada Rice Casserole

A bowl of rice with corn and herbs on a striped cloth with garnishes on the side.
Easy Chicken Enchilada Rice Casserole. Photo credit: Bagels and Lasagna.

All the flavors you love from chicken enchiladas, but with a fun twist! This casserole adds fluffy rice and layers of cheese, chicken, and enchilada sauce for a standout dinner.
Get the Recipe: Easy Chicken Enchilada Rice Casserole

Philly Cheesesteak Casserole

Image shows a wooden spatula cutting philly cheesesteak casserole from baking dish.
Philly Cheesesteak Casserole. Photo credit: Primal Edge Health.

Bring the bold flavors of Philly to your dinner table with this cheesy, meaty casserole loaded with juicy beef, sautéed peppers, and onions.
Get the Recipe: Philly Cheesesteak Casserole

Cuban Sandwich Casserole

A piece of Cuban sandwich casserole on a plate with potato chips.
Cuban Sandwich Casserole. Photo credit: Cook What You Love.

If you love the vibrant flavors of a Cuban sandwich, you’ll love this baked version! Juicy layers of pork, ham, cheese, and mustard combine for a flavor-packed dinner.
Get the Recipe: Cuban Sandwich Casserole

Easy Cheesy Hamburger Casserole

Easy cheesy hamburger casserole in bowl with onion garnish.
Easy Cheesy Hamburger Casserole. Photo credit: Recipes From Leftovers.

This one’s all about simplicity and bold flavor! Juicy ground beef, gooey cheese, and hearty pasta come together in a crowd-pleaser that’s a breeze to whip up.
Get the Recipe: Easy Cheesy Hamburger Casserole

Ground Beef and Broccoli Casserole

A baked casserole dish with ground beef and broccoli casserole and a wooden spoon.
Ground Beef and Broccoli Casserole. Photo credit: Primal Edge Health.

A healthier twist on casserole night, this dish pairs seasoned ground beef with crunchy broccoli and creamy sauce for a delicious dinner loaded with nutrients.
Get the Recipe: Ground Beef and Broccoli Casserole

Egg Casserole with Ground Beef

A person cutting a piece out of a casserole.
Egg Casserole with Ground Beef. Photo credit: Primal Edge Health.

Savory ground beef, fluffy eggs, and a medley of veggies make this hearty casserole a satisfying meal for breakfast, lunch, or dinner.
Get the Recipe: Egg Casserole with Ground Beef

One Pot Cheesy Sausage and Rice Casserole

A close-up of a plate of cheesy sausage jambalaya, featuring sliced sausage, melted cheese, and rice, garnished with herbs.
One Pot Cheesy Sausage and Rice Casserole. Photo credit: Bagels and Lasagna.

Minimal dishes, maximum flavor! This all-in-one casserole is loaded with smoky sausage, fluffy rice, and gooey cheese for a dish that’s as quick as it is comforting.
Get the Recipe: One Pot Cheesy Sausage and Rice Casserole

A woman with shoulder-length blonde hair, wearing a white T-shirt and dark jeans, stands in a kitchen with a brick backsplash and stainless steel appliances. She is smiling and resting her hands on the counter.

About the author

Hi, I’m Lucy! I’m a home cook, writer, food and wine fanatic, and recipe developer. I’ve created and tested hundreds of recipes so that I can bring you the best tried and true favorites.

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